Sally N Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Meters Rexrode, Association ranging from consumption off magnesium, potassium, and you can calcium supplements and you may chance of coronary attack: 2 cohorts of us female and updated meta-analyses, The brand new American Log regarding Systematic Diet, Volume 101, Thing six, , Profiles 1269–1277,
Conceptual
Background: Potential investigation to your family relations of magnesium, potassium, and calcium supplements intakes which have coronary arrest chance is contradictory, and also to all of our knowledge, the effect regarding a combined mineral diet rating wasn’t looked at.
Objective: I examined contacts anywhere between intakes from magnesium, potassium, and you can calcium and you will likelihood of experience stroke inside the 86,149 feamales in the brand new Nurses’ Fitness Study (NHS) We and you https://datingranking.net/hindu-dating/ may 94,715 women in this new NHS II.
Design: Within potential cohort analysis, we computed Hrs away from coronary arrest by the quintiles off consumption for each and every nutrient and a mixed diet plan score of all the step 3 nutritional elements that with multivariate Cox proportional possibility habits. As well, i updated meta-analyses on fat reduction intakes ones nutrition and you can threat of heart attack.
Results: Throughout follow-right up (30 y in the NHS We; twenty-two y on the NHS II) a maximum of 3780 event stroke circumstances was basically documented. Pooled multivariate RRs out of total stroke for ladies regarding the higher compared with a reduced quintiles have been 0.87 (95% CI: 0.78, 0.97) to have complete magnesium, 0.89 (95% CI: 0.80, 0.99) having overall potassium, and 0.97 (95% CI: 0.87, 1.09) to own total calcium consumption. Pooled RRs for ladies throughout the highest compared to a reduced quintiles out-of a mixed mineral diet plan score were 0.72 (95% CI: 0.65, 0.81) getting overall coronary attack, 0.78 (95% CI: 0.66, 0.92) having ischemic coronary attack, and you can 0.80 (95% CI: 0.61, step 1.04) having hemorrhagic coronary attack. On the upgraded meta-analyses of the many prospective degree to date, the fresh new combined RR regarding total coronary arrest is 0.87 (95% CI: 0.83, 0.92) to have a hundred-mg/d increase in magnesium intake, 0.91 (95% CI: 0.88, 0.94) for a great one thousand-mg/d escalation in potassium intake, and you can 0.98 (95% CI: 0.94, 1.02) to own a three hundred-mg/d rise in calcium supplements intake.
Conclusions: A combined mineral eating plan score try inversely on the likelihood of coronary attack. Highest consumption from magnesium and you will potassium yet not calcium supplements have been and rather for the faster danger of stroke in women.
Inclusion
Magnesium is a vital nutrient and cofactor for >3 hundred enzymatic reactions in your body ( 1). Magnesium is the second very-abundant intracellular cation near to potassium ( 2). Calcium supplements is one of-plentiful nutrient in your body. Such magnesium and you will potassium, calcium is actually critically working in cardiovascular qualities ( 3). Large fat reduction intakes of every ones nutrition was in fact stated so you’re able to down threat of blood pressure levels ( 4– 7), which is the principal modifiable coronary attack risk factor. Although not, only a few prospective studies looked at the family between weight reduction and you can extra consumption ones minerals and you may threat of heart attack in females, and you can abilities was in fact contradictory. Possible training in Europe displayed magnesium intake, not intake out-of potassium otherwise calcium, is significantly of the shorter likelihood of coronary arrest ( seven, 8). In the usa, intakes out of potassium and you may magnesium, yet not out-of calcium, was in fact with the less coronary arrest exposure during the males ( 9), whereas calcium supplements and potassium intakes, although not magnesium intake, was in fact of reduced coronary arrest risk in females ( 10). Plus, one to data demonstrated no overall connection ranging from any of these minerals and you may chance of coronary arrest ( 11).
Some of the potential observational training that were conducted did not include follow-upwards past 15 y and had a comparatively few event stroke occurrences, and in extremely education, this new separate aftereffect of for every single nutrient intake off medications and you will coronary attack models was not looked at. In this article, we provide facts to your connection of each and every mineral consumption from diet and drugs which have chance of overall, ischemic, and you may hemorrhagic experience strokes. In addition, i hypothesized that a blended diet score of all of the step 3 vitamins can be associated with the less coronary attack exposure mainly because vitamins can be found together with her inside the items, and you can consumption was strongly synchronised. I handled these types of seeks when you look at the You women that was in fact followed prospectively on the 2 large cohorts the newest Nurses’ Fitness Study (NHS) 5 I and you can II.