Sally N Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Meters Rexrode, Organization between consumption out of magnesium, potassium, and calcium and you will danger of coronary arrest: 2 cohorts folks female and you may current meta-analyses, The brand new Western Record out of Medical Nutrients, Frequency 101, Point 6, , Profiles 1269–1277,
Conceptual
Background: Potential analysis towards family relations out of magnesium, potassium, and you can calcium consumption with heart attack exposure try contradictory, also to all of our education, the end result from a mixed mineral diet plan score wasn’t checked out.
Objective: We examined relationships anywhere between intakes out of magnesium, potassium, and you may calcium and danger of experience coronary attack from inside the 86,149 ladies in new Nurses’ Wellness Study (NHS) I and you can 94,715 ladies in the fresh new NHS II.
Design: Contained in this prospective cohort analysis, we computed Time off stroke by quintiles from intake for every single mineral as well as for a combined diet score of all of the step three minerals by using multivariate Cox proportional chances habits. On top of that, i updated meta-analyses for the weight-loss intakes of those vitamins and danger of coronary attack.
Results: Throughout go after-up (29 y on NHS I; 22 y about NHS II) a total of 3780 experience coronary attack cases have been documented. Pooled multivariate RRs out-of overall stroke for females regarding large compared to a minimal quintiles had been 0.87 (95% CI: 0.78, 0.97) getting overall magnesium, 0.89 (95% CI: 0.80, 0.99) to own full potassium, and you can 0.97 (95% CI: 0.87, 1.09) getting full calcium intake. Pooled RRs for females regarding the higher compared with the lowest quintiles off a mixed nutrient diet plan rating was in fact 0.72 (95% CI: 0.65, 0.81) to have overall coronary arrest, 0.78 (95% CI: 0.66, 0.92) to have ischemic coronary attack, and you can 0.80 (95% CI: 0.61, step one.04) getting hemorrhagic stroke. On upgraded meta-analyses of all of the possible training thus far, the brand new mutual RR regarding total heart attack is actually 0.87 (95% CI: 0.83, 0.92) to own an one hundred-mg/d escalation in magnesium consumption, 0.91 (95% CI: 0.88, 0.94) having an excellent 1000-mg/d upsurge in potassium intake, and you can 0.98 (95% CI: 0.94, step 1.02) having a 300-mg/d upsurge in calcium consumption.
Conclusions: A blended nutrient eating plan rating are inversely on the chance of heart attack. High consumption off magnesium and you can potassium yet not calcium was indeed plus rather of quicker risk of heart attack in women.
Introduction
Magnesium is a vital nutrient and cofactor getting >300 enzymatic reactions in the human body ( 1). Magnesium ‘s the 2nd very-plentiful intracellular cation alongside potassium ( 2). Calcium is the most-numerous nutrient in the human body. Particularly magnesium and you may potassium, calcium supplements was significantly employed in cardio features ( 3). High weightloss consumption each and every of these nutritional elements was basically claimed in order to down chance of blood pressure level ( 4– 7), the dominant modifiable stroke exposure basis. But not, not all potential studies examined the fresh new loved ones ranging from weight-loss and you will extra intakes of them nutrients and you may likelihood of coronary attack in females, and you can efficiency were inconsistent. Prospective training inside European countries displayed magnesium consumption, not intake out of potassium or calcium, try notably associated with the shorter danger of heart attack ( seven, 8). In the united states, intakes away from potassium and you can magnesium, although not regarding calcium, was in fact of this shorter coronary attack exposure inside the guys ( 9), while calcium supplements and you will potassium consumption, yet not magnesium intake, have been in the less heart attack chance in females ( 10). And additionally, one study shown zero overall connection anywhere between any of these minerals and threat of heart attack ( 11).
The prospective observational training which were conducted failed to tend to be follow-right up past fifteen y along with a fairly small number of experience coronary attack situations, as well as in extremely training, the separate effectation of for each and every mineral intake away from tablets and you can heart attack products wasn’t looked at. In this article, you can expect research into association of each mineral intake out of dieting and supplements that have threat of overall, ischemic, and you will hemorrhagic event shots. While doing so, we hypothesized you to definitely a combined eating plan rating of the many step 3 nutritional elements is generally associated with reduced heart attack exposure because these nutrition exist with her in products, and you can intakes are firmly correlated Russian dating app. We managed these types of aims into the You women that was basically implemented prospectively on 2 highest cohorts the brand new Nurses’ Health Investigation (NHS) 5 I and you will II.